Publications
2025
- Evangelos J Giamarellos-Bourboulis, Antigone Kotsaki, Ioanna Kotsamidi, Aikaterini Efthymiou, Vasiliki Koutsoukou, Johannes Ehler, Alexandra Paridou, Frantzeska Frantzeskaki, Marcella C A Müller, Peter Pickkers, Sylvain Meylan, Ioannis Nikolopoulos, Mihaela Lupse, Alexandra Gavala, Glykeria Vlachogianni, Nicky Solomonidi, Antonia Alevizou, Eumorfia Kondili, Eleni Antoniadou, Maria Nakou, Nikolaos Markou, Erifili Hatziagelaki, Athanassios Prekates, Apostolos Komnos, Lieke Bakkerus, Marleen A Slim, George N Dalekos, Areti Karapanagiotou, Sofia Ktena, Gennaro De Pascale, Vassileios Koulouras, Christos Psarrakis, Eleni Massa, Konstantina Dakou, Chrisoula Pazvanti, Aikaterini Ioakeimidou, Iraklis Tsangaris, Nikolaos Antonakos, Alexander P J Vlaar, Souzana Anisoglou, Thierry Calandra, Vasilios Papaioannou, Pavlos Myrianthefs, Maria Patrani, Ioannis Alamanos, Massimo Antonelli, Jos W M van der Meer, Tom van der Poll, W Joost Wiersinga, Maria Ntaganou, Eleni Gkeka, Michael Bauer, Eleni Mouloudi, Mihai G Netea; ImmunoSep Study Group doi: 10.1001/jama.2025.24175
Question Does immunotherapy tailored to the type of immune dysregulation improve outcomes among patients with sepsis?
Findings In this multicenter randomized clinical trial of 276 patients, precision immunotherapy, which included the administration of anakinra for patients with macrophage activation–like syndrome and recombinant human interferon gamma for patients with sepsis-induced immunoparalysis, decreased the Sequential Organ Failure Assessment score by at least 1.4 points by day 9 in 35.1% of patients in the immunotherapy group vs 17.9% in the placebo group.
Meaning A precision strategy of immunotherapy improved organ dysfunction at day 9 among patients with sepsis.
2024
- Irene T. Schrijver, Jacobus Herderschee, Charlotte Théroude, Antonios Kritikos, Guus Leijte, Didier Le Roy, Maelick Brochut, Jean-Daniel Chiche, Matthieu Perreau, Giuseppe Pantaleo, Benoit Guery, Matthijs Kox, Peter Pickkers, Thierry Calandra, Thierry Roger doi: 10.3390/cells13040314
- Marleen A. Slim, Niels van Mourik, Lieke Bakkerus, Katherine Fuller, Lydia Acharya, Tatiana Giannidis, Joanna C. Dionne, Simon J. W. Oczkowski, Mihai G. Netea, Peter Pickkers, Evangelos J. Giamarellos-Bourboulis, Marcella C. A. Müller, Tom van der Poll, W. Joost Wiersinga, null null, Bart-Jan Kullberg, Aline Nooijer, Frank Veerdonk, Jaap Oever, Jacobien Hoogerwerf, Marlies Hulscher, Mihai Netea, Anke Oerlemans, Athanasios Ziogas, Julie Swillens, Lisa Berg, Nynke Bos, Matthijs Kox, Leda Estratiou, Evangelos Giamarellos-Bourboulis, Antigoni Kotsaki, Antonakos Nikolaos, Gregoriadis Spyros, Thierry Calandra, Sylvain Meylan, Tiia Snaka, Thierry Roger, Michael Bauer, Frank Brunkhorst, Frank Bloos, Sebastian Weis, Willy Hartman, Marleen Slim, Lonneke Vught, Alexander Vlaar, Marcela Muller, Joost Wiersinga, Mihaela Lupse, Grigore Santamarean, Thomas Rimmele, Filippo Conti, Guillaume Monneret, Anna Aschenbrenner, Joachim Schultze, Martina Uelft, Christoph Bock, Robert terHorst, Irit Gat-Viks, Einat Ron, Gal Yunkovitz, Sophie Ablott, Estelle Peronnet, Margaux Balezeaux, Adrien Saliou, Julie Hart, Alexander P. J. Vlaar, Lonneke A. van Vught doi: https://doi.org/10.1186/s13054-024-04964-6
- Evangelos J. Giamarellos-Bourboulis, Anna C. Aschenbrenner, Michael Bauer, Christoph Bock, Thierry Calandra, Irit Gat-Viks, Evdoxia Kyriazopoulou, Mihaela Lupse, Guillaume Monneret, Peter Pickkers, Joachim L. Schultze, Tom van der Poll, Frank L. van de Veerdonk, Alexander P. J. Vlaar, Sebastian Weis, W. Joost Wiersinga, Mihai G. Netea doi: https://doi.org/10.1038/s41590-023-01660-5
- Rainer Knoll, Elisa T. Helbig, Kilian Dahm, Olufemi Bolaji, Frederik Hamm, Oliver Dietrich, Martina van Uelft, Sophie Müller, Lorenzo Bonaguro, Jonas Schulte-Schrepping, Lev Petrov, Benjamin Krämer, Michael Kraut, Paula Stubbemann, Charlotte Thibeault, Sophia Brumhard, Heidi Theis, Gudrun Hack, Elena De Domenico, Jacob Nattermann, Matthias Becker, Marc D. Beyer, David Hillus, Philipp Georg, Constantin Loers, Janina Tiedemann, Pinkus Tober-Lau, Lena Lippert, Belén Millet Pascual-Leone, Frank Tacke, Gernot Rohde, Norbert Suttorp, Martin Witzenrath, Antoine-Emmanuel Saliba, Thomas Ulas, Julia K. Polansky, Birgit Sawitzki, Leif E. Sander, Joachim L. Schultze, Anna C. Aschenbrenner, Florian Kurth doi: 10.1016/j.cell.2024.06.014
2023
- Lokesh Sharma, Shaon Sengputa, Thierry Roger doi: 10.3389/fimmu.2023.1194826
- Amit Frishberg, Neta Milman, Ayelet Alpert, Hannah Spitzer, Ben Asani, Johannes B. Schiefelbein, Evgeny Bakin, Karen Regev-Berman, Siegfried G. Priglinger, Joachim L. Schultze, Fabian J. Theis, Shai S. Shen-Orr doi: https://doi.org/10.1038/s41467-023-42354-8
- Rainer Knoll, Lorenzo Bonaguro, Jéssica C. dos Santos, Stefanie Warnat-Herresthal, Maartje C. P. Jacobs-Cleophas, Edda Blümel, Nico Reusch, Arik Horne, Miriam Herbert, Melanie Nuesch-Germano, Twan Otten, Wouter A. van der Heijden, Lisa van de Wijer, Alex K. Shalek, Kristian Händler, Matthias Becker, Marc D. Beyer, Mihai G. Netea, Leo A. B. Joosten, Andre J. A. M. van der Ven, Joachim L. Schultze, Anna C. Aschenbrenner doi: 10.3389/fimmu.2023.1275136
- Sophie Müller, Charlotte Kröger, Joachim L. Schultze, Anna C. Aschenbrenner doi: https://doi.org/10.1002/eji.202350519
2022
- Antigone Kotsaki, Peter Pickkers, Michael Bauer, Thierry Calandra, Mihaela Lupse, W Joost Wiersinga, Sylvain Meylan, Frank Bloos, Tom van der Poll, Marleen A Slim, Niels van Mourik, Marcella C A Müller, Lonneke van Vught, Alexander P J Vlaar, Aline de Nooijer, Lieke Bakkerus, Sebastian Weis, Nikolaos Antonakos, Mihai G Netea, Evangelos J Giamarellos-Bourboulis doi: https://bmjopen.bmj.com/content/12/12/e067251
- Nikolaos Antonakos, Charly Gilbert, Charlotte Théroude, Irene T Schrijver, Thierry Roger doi: 10.3389/fimmu.2022.951798
- Marleen A Slim, Niels van Mourik, Joanna C Dionne, Simon J W Oczkowski, M G Netea, Peter Pickkers, Evangelos J Giamarellos-Bourboulis, Marcella C A Müller, Tom van der Poll, W Joost Wiersinga, Alexander P J Vlaar, Lonneke A van Vught doi: 10.1136/bmjopen-2021-060411
- Ofir Cohn, Gal Yankovitz, Naama Peshes-Yaloz, Yael Steuerman, Amit Frishberg, Rachel Brandes, Michal Mandelboim, Jennifer R. Hamilton, Tzachi Hagai, Ido Amit, Mihai G. Netea, Nir Hacohen, Fuad A. Iraqi, Eran Bacharach, Irit Gat-Viks doi: 10.1101/2022.03.22.485254
2021
- Amit Frishberg, Inge van den Munckhof, Rob ter Horst, Kiki Schraa, Leo AB Joosten, Joost HW Rutten, Adrian C Iancu, Ioana M Dregoesc, Bogdan A Tigu, Mihai G Netea, Niels P Riksen, Irit Gat-Viks doi: 10.7554/elife.61710
- Alex R. Schuurman, Tom D. Y. Reijnders, Robert F. J. Kullberg, Joe M. Butler, Tom van der Poll, W. Joost Wiersinga doi: 10.1186/s40635‑021‑00383‑x
- Ioannis Kourtzelis, James Hewitson, Thierry Roger doi: 10.3389/fimmu.2021.823023
2020
- Evangelos J. Giamarellos-Bourboulis, Mihai G. Netea, Nikoletta Rovina, Karolina Akinosoglou, Anastasia Antoniadou, Nikolaos Antonakos, Georgia Damoraki, Theologia Gkavogianni, Maria-Evangelia Adami, Paraskevi Katsaounou, Maria Ntaganou, Magdalini Kyriakopoulou, George Dimopoulos, Ioannis Koutsodimitropoulos, Dimitrios Velissaris, Panagiotis Koufargyris, Athanassios Karageorgos, Konstantina Katrini, Vasileios Lekakis, Mihaela Lupse, Antigone Kotsaki, George Renieris, Danai Theodoulou, Vassiliki Panou, Evangelia Koukaki, Nikolaos Koulouris, Charalambos Gogos, Antonia Koutsoukou doi: 10.1016/j.chom.2020.04.009
- George Dimopoulos, Quirijn de Mast, Nikolaos Markou, Maria Theodorakopoulou, Apostolos Komnos, Maria Mouktaroudi, Mihai G Netea, Themistoklis Spyridopoulos, Rebecca J Verheggen, Jacobien Hoogerwerf, Alexandra Lachana, Frank L van de Veerdonk, Evangelos J Giamarellos-Bourboulis doi: 10.1016/j.chom.2020.05.007
- Luregn J Schlapbach, Joahnnes Trück, Thierry Roger doi: 10.3389/fimmu.2020.01263
Related Publications
- Konstantinos Leventogiannis, Evdoxia Kyriazopoulou, Nikolaos Antonakos, ..., Miltiades Kyprianou, Mihai G. Netea, Evangelos J. Giamarellos-Bourboulis doi: https://doi.org/10.1016/j.xcrm.2022.100817
- Evdoxia Kyriazopoulou, Garyfallia Poulakou2, Haralampos Milionis, Simeon Metallidis, Georgios Adamis, Konstantinos Tsiakos, Archontoula Fragkou, Aggeliki Rapti, Christina Damoulari, Massimo Fantoni, Ioannis Kalomenidis, Georgios Chrysos, Andrea Angheben, Ilias Kainis, Zoi Alexiou, Francesco Castelli, Francesco Saverio Serino, Maria Tsilika, Petros Bakakos, Emanuele Nicastri, Vassiliki Tzavara, Evangelos Kostis, Lorenzo Dagna, Panagiotis Koufargyris, Katerina Dimakou, Spyridon Savvanis, Glykeria Tzatzagou, Maria Chini, Giulio Cavalli, Matteo Bassetti, Konstantina Katrini, Vasileios Kotsis, George Tsoukalas, Carlo Selmi, Ioannis Bliziotis, Michael Samarkos, Michael Doumas, Sofia Ktena, Aikaterini Masgala, Ilias Papanikolaou, Maria Kosmidou, Dimitra-Melia Myrodia, Aikaterini Argyraki, Chiara Simona Cardellino, Katerina Koliakou, Eleni-Ioanna Katsigianni, Vassiliki Rapti, Efthymia Giannitsioti, Antonella Cingolani, Styliani Micha, Karolina Akinosoglou, Orestis Liatsis-Douvitsas, Styliani Symbardi, Nikolaos Gatselis, Maria Mouktaroudi, Giuseppe Ippolito, Eleni Florou, Antigone Kotsaki, Mihai G. Netea, Jesper Eugen-Olsen, Miltiades Kyprianou, Periklis Panagopoulos, George N. Dalekos and Evangelos J. Giamarellos-Bourboulis doi: https://doi.org/10.1038/s41591-021-01499-z