Personalised Immunotherapy in Sepsis:
a precision medicine approach

Rheinische Friedrich-Wilhelms-Universität Bonn

— UBO —

The Life and Medical Sciences (LIMES) Institute fosters molecular research spanning from immunology to metabolism using a broad spectrum of cutting-edge technologies including state-of–the-art genomic technologies. LIMES plays a major role in the excellence cluster ImmunoSensation², is leading the key profile area Life and Health at UBO and is involved in the development of the interdisciplinary and integrative computing infrastructure at UBO. Moreover, UBO/LIMES host the Platform for Single Cell Genomics and Epigenomics (PRECISE), which is a joint venture between UBO and the German Center for Neurodegenerative Diseases (DZNE). PRECISE at LIMES/DZNE provides knowledge and experience in omics technologies and a platform that further supports the strong interaction of immunologists with computer scientists and computational biologists using state of the art tools and IT infrastructure.

Role within ImmunoSep

The Schultze group (UBO) established the PRECISE Platform for Single Cell Genomics and Epigenomics, which is a joint venture between UBO and the German Centre for Neurodegenerative Diseases (DZNE). PRECISE has established a streamlined platform for both the processing of cell-population-based RNA-seq samples and the fast, computational assessment of gene expression data. As our group is located in the interface between immunology, metabolic research, and neurosciences on one side and genomics and bioinformatics on the other side, we will provide insights into the immunological phenotype of sepsis patients using RNA-sequencing technologies. Here we analyse PBMC samples of patients of different groups via bulk RNA seq and single cell RNA seq over different time points. Based on that approach we aim to identify subpopulations of immune cells that may be responsible for the immune dysregulation in sepsis.

Main contacts

Photo of Prof. Dr. Joachim Schultze
Prof. Dr. Joachim Schultze
Photo of Dr. Anna Aschenbrenner
Dr. Anna Aschenbrenner
Photo of Dr. Thomas Ulas
Dr. Thomas Ulas
Photo of Melanie Nuesch
Melanie Nuesch
Photo of Dr. Martina van Uelft
Dr. Martina van Uelft